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Hello welcome to my Blog.

“Optimism is the faith that leads to achievement. Nothing can be done without hope and confidence”.

To me success means effectiveness in the world, that i am able to carry my ideas and values in the world- that i am able to change it in positive ways.

With my full pleasure i proudly  say that, i have currently joined with OSDD. Here I am doing my M.Tech final year project under the guidance of Dr.U.C.Jaleel, Principle Investigator,CSIR – OSDD research Unit, IISC, Bangalore.

  The motto of OSDD is “affordable health care for all”.

Open Source Drug Discovery (OSDD) is a CSIR led team India Consortium with global partnership with a vision to provide affordable healthcare to the developing world by providing a global platform where the best minds can collaborate & collectively endeavor to solve the complex problems associated with discovering novel therapies for neglected tropical diseases like Tuberculosis, Malaria, Leishmaniasis etc.

OSDD is a translational platform for drug discovery, bringing together informaticians, wet lab scientists, contract research organizations, clinicians, hospitals and others who are willing to adhere to the affordable healthcare philosophy agreeing to the OSDD license.

 click here to view OSDD (Open Source Drug Discovery)

     I wish to provide my full effort and contribution to this collaboration. I would like to express my knowledge to development of Drug for neglected tropical diseases with the help of OSDD.

 I am focusing the disease of malaria which is one of the neglected tropical disease.

Here I provide the details of malaria like what is malaria? How people get malaria? Symptoms and diagnoses as well as treatment. The following link having details as I mentioned above FAQs.

Center for Disease Control and Prevention.Here u can get all disease details.

There are many databases available for malaria.They are followed by,

1.Full-Malaria(malaria full length cDNA  Database) FULL-malaria has started as a database for a full-length cDNAs from human malaria parasite, Plasmodium falciparum. Now it contains full-length cDNAs from human malaria parasite, P. vivax and murine malaria parasites, P. yoelii and P. berghei. The protein sequences of the annotated genes of P. falciparum were used as queries to search homologous regions of the genome sequences of the other malaria parasites using TBLASTX program. Based on these homologies, the contig sequences of P. vivax, P. yoelii and P. berghei were aligned with the genome sequences of P. falciparum and displayed in the graphical genome viewer.

2.PlasmoDB: a functional genomic database for malaria parasites. PlasmoDB  is a functional genomic database for Plasmodium spp. that provides a resource for data analysis and visualization in a gene-by-gene or genome-wide scale. PlasmoDB belongs to a family of genomic resources that are housed under the EuPathDB Bioinformatics Resource Center (BRC) umbrella. The latest release, PlasmoDB 5.5, contains numerous new data types from several broad categories–annotated genomes, evidence of transcription, proteomics evidence, protein function evidence, population biology and evolution. Data in PlasmoDB can be queried by selecting the data of interest from a query grid or drop down menus. Various results can then be combined with each other on the query history page. Search results can be downloaded with associated functional data and registered users can store their query history for future retrieval or analysis.

3. RMgmDB:Rodent Malaria genetically modified DataBase. Genetically modified Plasmodium parasites are central gene function reagents in malaria research. The Rodent Malaria genetically modified DataBase (RMgmDB) is a manually curated Web – based repository that contains information on genetically modified rodent malaria parasites. It provides easy and rapid access to information on the genotype and phenotype of genetically modified mutant and reporter parasites. Here, we provide guidelines for generating and describing rodent malaria parasite mutants. Standardization in describing mutant genotypes and phenotypes is important not only to enhance publication quality but also to facilitate cross-linking and mining data from multiple sources, and should permit information derived from mutant parasites to be used in integrative system biology approaches. We also provide guidelines on how to submit information to RMgmDB on non-published mutants, mutants that do not exhibit a clear phenotype, as well as negative attempts to disrupt/mutate genes. Such information helps to prevent unnecessary duplication of experiments in different laboratories, and can provide indirect evidence that these genes are essential for blood-stage development.

More information about Malaria,

• Malarial Foundation International: This is one of the webpage about malaria.Their mission is to facilitate the development and implementation of solutions to the health, economic, and social problems caused by malaria.They listed the malaria genome databases.
• RollBack Malaria(RBM).RBM’s vision is of a world free from the burden of malaria.
• Discovery-2 : an interactive resource for the rational selection and comparison of putative drug target proteins in malaria. Discovery is a web interface for the discovery of possible malaria drug targets using various different protein properties and annotations. It can be searched using chemical compounds or protein keywords.
• World Malaria Day, annual observance held on April 25 to raise awareness of the global effort to control and ultimately eradicate malaria

Target proteins for malaria:

1.Malaria parasite protein identified as the potential target for drug treatment. click here to view full details

Here I provide the document of TARGET PROTEINS FOR MALARIA